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The enzymes concerned in lysine methylation were first discovered to focus on histone and thus have been initially named histone methyltransferases and histone demethylases, following the naming mannequin for histone acetyltransferase and histone deacetylase.
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In the last two decades, several studies demonstrated the significance of submit-translational modifications (PTM) in mobile development and several illnesses like cancer, but just lately protein lysine methylation has emerged as an another very important PTM.

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